Dofetilide: what role in the treatment of ventricular tachyarrhythmias?

Efficacy and safety of dofetilide in the treatment of frequent ventricular tachyarrhythmias after amiodarone intolerance or failure.

Dofetilide: is the treatment worse than the disease?

On October 1, 1999, the U.S. Food and Drug Administration (FDA) approved dofetilide (Tikosyn) for the treatment of persistent (nonparoxysmal) atrial fibrillation and flutter. However, the FDA cautioned: “Because Tikosyn can cause life-threatening ventricular arrhythmias, it should be reserved for patients in whom atrial fibrillation/flutter is highly symptomatic (1).” Dofetilide is the first ne...

A multicentre, double-blind randomized crossover comparative study on the efficacy and safety of dofetilide vs sotalol in patients with inducible sustained ventricular tachycardia and ischaemic heart disease.

BACKGROUND Antiarrhythmic drugs are still used for the treatment of ventricular tachyarrhythmias, in combination with implantable cardioverter-defibrillators or without them. AIM OF THE STUDY In a double-blind randomized crossover design, the short- and long-term efficacy and safety of oral dofetilide or oral sotalol were compared in 135 patients with ischaemic heart disease and inducible sus...

Antiarrhythmic drugs in patients with implantable cardioverter-defibrillators.

Antiarrhythmic drugs need to be initiated in up to 70% of patients with implantable cardioverter-defibrillators (ICDs) in order to treat atrial tachyarrhythmias, decrease the frequency of defibrillator shocks, and terminate ventricular arrhythmias along with antitachycardia pacing. trial fibrillation (AF) occurs in about 20% of patients with ICDs (the majority with congestive heart failure [CHF...

Simultaneous Determination of Dofetilide and Amlodipine in Plasma by HPLC

Dofetilide is a Class III antiarrhythmic drug useful in the management of atrial fibrillation but also known to prolong the QT interval on the ECG and to induce malignant ventricular tachyarrhythmias such as torsades de pointes (TDP). Drugs with calcium channel-blocking properties contribute to decrease the incidence of TDP. Amlodipine is a dihydropyridine calcium channel antagonist. Considerin...